Colloquium IE&IS/IS – W&I/IS July 4, 2014 @K.10 16.00 (+PVOC drink)

Nan Shan / Hui Yan / Pieter Van Gorp (BrainBridge)

After this talk a drink will take place in the PVOC.

Title: BrainBridge Project: Results after 2 years

Abstract: In this talk, we survey the work that has been performed during the first two years of the ongoing BrainBridge project on Clinical Pathway Support.  The project consists of two PhD projects (by Hui Yan and Shan Nan). The talk will consist of an introduction (by Pieter Van Gorp), a part of compliance analysis (by Hui Yan) and a part on a dynamic checklist support system (by Shan Nan). The introduction will sketch the project background as well as BPMN 2.0 formalization work, which we have used as the basis for the compliance analysis support.  The second part will describe novel BPMN 2.0 based compliance analysis support and its application to two clinical scenario’s.  The third part will describe the limitations of paper-based as well as static electronic checklist support, then it will introduce TraceBook, a BPMN 2.0 based dynamic checklist support system that interfaces to the EMR and CDSS of the Catharina Hospital and which has interfaces for integrating other systems.  Finally, we will describe ongoing work, which primarily consists of maturing the aforementioned results and evaluating them in a clinical setting.

Related literature:

– Pieter Van Gorp and Remco Dijkman. BPMN 2.0 Execution Semantics Formalized as Graph Rewrite Rules. Information and Software Technology Volume 55, Issue 2, February 2013, Pages 365–394. DOI: 10.1016/j.infsof.2012.08.014.

– Hui Yan, Pieter Van Gorp, Uzay Kaymak, Xudong Lu, Richard Vdovjak, Hendriks H.M. Korsten, and Huilong Duan. Analyzing Conformance to Clinical Protocols Involving Advanced Synchronizations. Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on. pp. 61-68. DOI: 10.1109/BIBM.2013.6732601.

– Shan Nan, Pieter Van Gorp, Hendrikus H.M. Korsten, Richard Vdovjak, Uzay Kaymak, Xudong Lu and Huilong Duan. Tracebook: A Dynamic Checklist Support System 27th IEEE International Symposium on Computer-Based Medical Systems (CBMS 2014); Icahn School of Medicine at Mount Sinai, New York NY. May 2014.


Play your favorite games, together.


The European population is aging. Moreover, family and friend circles are compromised by the busy schedules of working citizens. It is already challenging balance between professional goals and duties, personal fitness and leisure activities as well as family (i.e., quality) time, especially involving multiple generations. The expected mobility of the active workers puts additional pressure on this. At the same time, there is economic need and corresponding political pressure for keeping the elderly longer at home, independent of managed care. Unless we provide new ways to empower European citizens, the anticipated economic benefits will be hindered by a too high pressure on families and home care organizations.


GameBus will provide a novel App to turn currently perceived duties regarding cognitive, physical and social activities into an enjoyable gaming experience. The key idea is to let people play the different games they enjoy truly as an individual in such a way that they are part of an integrated social interaction. Among others, elderly will be able to play their favorite brain training game (e.g., Sudoku) while joining forces with their younger peers that go out for a physical activity (e.g., running). Game players stimulate each other in order to achieve team goals, which favors their health directly. Implicitly, the game sessions will also counter social isolation and unconsciously vulnerable elderly will be monitored against cognitive decline too. Finally, GameBus will generate rich, integrated data (related to cognitive, physical, and social activities) with big commercial and scientific potential.

More Information

We have secured funding to bring this concept to reality in 2015 and scale it up in 2016.  Please see and

Project Harvesting SPR repair materials

The Information Systems group is often contacted by industrial organizations with assignments that could lead to student projects at various levels (master thesis project, bachelor completion project, etc.) Through this website we make these topics available to our students. In this post, we announce one such project, involving company Philips.

Background, Present situation:
De Service Parts & Repair afdeling repareert onderdelen (“artikelen”) van medische systemen die in het ziekenhuis defect zijn gegaan voor de Service Parts Supply chain organisatie (SPS) van Philips Healthcare. Met regelmaat kunnen artikelen als geheel niet gerepareerd worden wat betekent dat het in zijn geheel wordt afgevoerd. Er kunnen echter nog bruikbare onderdelen zitten in het af te voeren artikel die bij overige reparaties hergebruikt kunnen worden. Nu maakt men hier géén gebruik van daar het huidige repair proces en SAP systeem hier niet op is ingericht.

Reason why this project is nessecary:
Beoogde efficientie verbetering en kosten besparing binnen de service parts & repair afdeling door hergebruik van onderdelen en tegelijkertijd de afvalstroom reduceren met minder milieubelasting tot gevolg.

De afstudeeropdracht bevat:
1. een haalbaarheidsstudy met daarin de volgende aspecten:
-het opzetten van een business case om mogelijke besparing in kaart te brengen (voornamelijk vanuit financieel oogpunt)
-het toetsen van de uitvoerbaarheid in de huidige SAP omgeving en de mogelijke vereiste aanpassingen daarin
-een 1e opzet van het proces en vereiste wijze van werken (vanuit SAP en logistiek oogpunt)
-het toetsen van de eisen & richtlijnen vanuit Quality & Regulatory, finance oogpunt etc.
op basis waarvan een go/no go beslissing tot implementatie kan worden genomen,
2. de implementatie: het SAP technisch en logistiek (supply chain) inrichten van een compliant process (bij positieve haalbaarheids study), en
3. het opleveren van een procesbeschrijving en benodigde werkinstructies
om onderdelen van niet te repareren artikelen te kunnen hergebruiken via binnen de SAP MBP omgeving op een wijze die voldoet aan gestelde eisen & richtlijnen.
Bij een negatieve business case zal het vervolg van de afstudeeropdracht in onderling overleg opnieuw gedefinieerd moeten worden.

Expect result:
Een kostenbestaring en reductie in af te voeren materialen (minder milieubelastend) als gevolg van hergebruik van onderdelen van niet te repareren artikelen middels een proces wat voldoet aan geldende eisen & richtlijnen binnen de huidige SAP MBP omgeving.

Candidate profile:
De afstudeerder dient een informatie technology/IT study te volgen (liefst met basis SAP kennis) en een haalbaarheidsstudy uit te kunnen voeren waarin een (met name financiele) business case opgezet dient te worden en processen getoetst worden t.o.v. geldende eisen & richtlijnen (o.a. vanuit financieel en quality & regulatory oogpunt)

Contact for more information: Rik Eshuis

Project Visual Management Philips Healthcare

The Information Systems group is often contacted by industrial organizations with assignments that could lead to student projects at various levels (master thesis project, bachelor completion project, etc.) Through this website we make these topics available to our students. In this post, we announce one such project, involving company Philips.

Background, Present situation:
Daily start-up meetings in Operations are using data to provide overview of performance and to support scheduling and decisions. These data are (partly real time) maintained and daily presented in Microsoft Excel format. Examples of data used: people & production planning, availability of components, quality issues, safety issues, actions and improvements.

Reason why this project is nessecary:
At present there is no full standardisation between production teams regarding data content and means of presentation. Available systems are not user friendly with respect to filling, maintaining and presenting. Avalable systems are not following the Philips Lean guidelines.

Design and introduce a standardised and robust visual management system for daily start up, which can be used in all MR Operations teams in Best, using available data and following Philips Lean guidelines.

Expect result:
The system has to work and to be robust and easy to maintain. Users (Unit Managers, Team Leaders, Shop Floor Controllers, Operators) will be trained to enter data and to present. The design will be carried over to the designated key user (Production Controller).

Contact for more information: Rik Eshuis

Presentation Stan N. Finkelstein (MIT)

Stan N. Finkelstein, MD (Senior Research Scientist, Massachusetts Institute of Technology, Engineering Systems Division;Associate Professor of Medicine, Harvard Medical School)

When: Event


Please confirm your attendance by sending an email to

Title: Finding New Lives for Old Drugs: Ideas about using a Systematic Approach

Abstract: When drugs are approved by regulatory agencies like the European Medicines Agency and the U.S. Food and Drug Administration to enter the market, they are labeled only for specific therapeutic uses, for which detailed evidence from clinical trials established their safety and efficacy. For many of these drugs, sooner or later, some evidence emerges (or at least a good reason to believe) that they would be efficacious for other uses, often referred to as “off-label uses”. In the U.S., prescribing of medicines for off-label uses, by qualified physicians is perfectly legal, though pharmaceutical companies would be breaking the law if they advertised or promoted them for such unauthorized uses. Such off-label uses are only
occasionally the object of later clinical trials to confirm their therapeutic value.

In this seminar, I will begin by reviewing evidence from a data-based study that examined the proportion of all drug prescribing that is off-label and identified the kinds of medicines that are most often used in this fashion. Then I will share some ideas and plans for new research aimed at systematically identifying medicines whose off-label uses could be evaluated through the conduct of “pseudo-trials,” using matched patient cohorts from electronic medical record databases.

The ultimate objective is to develop convincing evidence of these additional therapeutic uses of older drugs, in order that they can be prescribed more widely, and enable more patients to benefit from them.

Speaker Bio: Stan N. Finkelstein, M.D. is a Senior Research Scientist in the the MIT Engineering Systems Division. He also serves as Associate professor of Medicine at Harvard medical School and is a member of the faculty of the Division of Clinical Informatics at Beth Israel Deaconess Medical Center. He received his Masters of Science and Bachelors of Science degrees in
Chemical Engineering from MIT in 1971, and an M.D. from Harvard Medical School in 1975.

Since 1975, he has worked actively in the field of medical technology assessment and transfer at MIT. He conducts research and teaches classes in the development and evaluation of medical practice and technology and in health economics and policy, both at MIT and Harvard Medical School.

An active consultant to U.S. and international pharmaceutical, biotechnology, and medical device firms, as well as to health services organizations and government agencies; Dr. Finkelstein is an expert in outcomes research. His areas of specialization extend to the business-government interface related to medical technology, especially product development, clinical research design and third-party reimbursement. Dr. Finkelstein is author, editor, or contributor to several books and numerous articles on these subjects.

Dr. Finkelstein’s current research interests include analyses relating to the economics of illness and pharmaceutical treatment and to low probability, high consequence public health events. His publications include studies of cost of illness and cost-effectiveness of treatment. He is co-author of several recent articles that address the link between treatment of illness and productivity at work, and the role of advancing science and technology in changing patterns of medical treatment.

Nominations Industria Education Awards 2013

Every year, Industria organizes the Education Awards ceremony. Awards will be handed out to the best lecturers of 2012-2013 in four categories: Propedeuse (First year Bachelor), Post-propedeuse (second and third year Bachelor), Innovation Management and Operations Management and Logistics.

Irene Vanderfeesten and Pieter Van Gorp are amongst the nominees! Irene is nominated for Post propedeuse as well as Operations Management and Logistics. Pieter is nominated for Post propedeuse.
Industria Education Awards 2013

Venue Event

31 October 2013; The drink starts at 16.00h, and the official ceremony starts at 17.00h.
The Villa, Eindhoven

New Employee Bilge Celik Aydin

I am graduated from Industrial Engineering Department from Middle East Technical University in 2009. I completed my MSc degree in 2011 there while working as a teaching assistant. I have assisted courses such as simulation, systems thinking, network flow, work systems analysis and design, data mining and so on.
I focused on data mining and multi criteria optimization during my masters studies. For my thesis, I developed a distance-based multi-criteria optimization algorithm for the sorting problem.
I was involved in an applied project in KU Leuven last year about process improvement in the emergency department of Turnhout Hospital. We developed an advanced simulation model of the department based on the real data provided by the hospital. What-if analysis is conducted for evaluating the performance of different schedules. The project continues with integration of a genetic algorithm for staff schedules with the simulation model.