Master Thesis defense by Maarten Kooijman on GameBus

On Monday, February 15th, 2016, Maarten Kooijman will defend his master thesis entitled “The potential of a mobile health rewarding app (GameBus) for people with  Intellectual disabilities”.  Everyone is cordially invited to join to learn, ask questions and give feedback.

Where: TU/e, Paviljoen building, room K10

When: 13:00-14:00


  • Supervisors TU/e: Dr. P.M.E. (Pieter) Van Gorp, Prof. Dr. J.H.D.M (Joyce) Westerink
  • Supervisors Lunet Zorg (the home care organization at which the practical work was performed): P. (Patrick) Leijte, R. (Ruud) Kavelaars, H.J. (Henk) van Heffen


Abstract: This research describes the results of a six-month graduation project within the GameBus project. GameBus is a novel app, developed within a multinationality collaboration. The app engages families and friends to stay active physically, cognitively and socially via an enjoyable personalized gaming experience. GameBus connects children, colleagues, the elderly and other family members to join physical, cognitive and social challenges, and it is unique because it crosses the boundaries of existing health apps. The app was not designed explicitly for people with intellectual disabilities. However, some issues (e.g., social isolation, insufficient physical exercise, etc.) play a role in the care for people with intellectual disabilities, as they do in care for the elderly. Therefore, it is worthwhile to investigate if health-rewarding apps like GameBus can play a role within healthcare organizations for people with intellectual disabilities. Via this master thesis project, it has been examined which clients are eligible for GameBus and how the app might be used in the future. The findings and experiences of clients and client supervisors with the application of GameBus are presented. Three promising use cases were found in which GameBus can play a role. GameBus is a valuable way to motivate and stimulate clients to perform physical, social, cognitive and other (e.g., domestic) activities.

Master Thesis project of Tim Kleinloog featured in ChipSoft’s magazine “Mediair”


Professor Uzay Kaymak van de TU Eindhoven leidt het team dat onderzoek doet naar de toepassing van dataonderzoek in de zorg. Gertruud Krekels zorgt samen met haar collega Milan Tjioe voor de zorginhoudelijke input, het team bestaat daarnaast uit een groep onderzoekers van de universiteit. Een belangrijke rol is weggelegd voor Tim Kleinloog, die bij ChipSoft op dit onderwerp afstudeert.

Tim (24) studeert Technische Bedrijfskunde aan de TU Eindhoven en volgt de master ‘Innovation Management’. De titel van zijn onderzoek is ‘A data driven approach to evaluate guidelines for non-melanoma skin cancers (NMSKs)’. “Ik ontwikkel en test de manier waarop Getruud Krekels en Milan Tjioe informatie uit HiX halen om te evalueren hoe de klinische richtlijnen worden gevolgd. Een mooi project, want het is een ideale combinatie tussen ICT, zorg, wetenschappelijk onderzoek, analyseren en programmeren. Heel boeiend om er op deze manier aan bij te dragen dat HiX zorgverleners nóg beter kan ondersteunen.”

IS-HEART session on Simulation in Healthcare

Speaker: Geovanny Correa Cevallos (master thesis student in Operations Management and Logistics)

Title: Computer simulation applied to interventions in healthcare: Literature Review

Abstract: When ethical principles and financial convenience enter in the game, it is necessary to have a tool to evaluate possible changes in policies and norms.  The use of computer simulation is being proved very useful in this matter in the context of healthcare. The purpose of this presentation will be to show the results of the literature review after going through some basic concepts about simulation, intervention research, what are the available methods, and which of those fit better with the purpose of applying computer simulation in evaluating healthcare systems. At the end, the methodology proposed by Sobolev et al. (2012) is presented as a reference to conduct such type of simulation. Furthermore it will be mentioned a chance for improvement in the implementation of this method given the automatic translation method suggested by Eshuis & Van Gorp (2014)

When/where: April 24th, 2015, in K16 (see agenda).

Master Thesis Defense Sven Bastianen: Towards an architecture for the support of integrated Personal Health Records

Pieter Van Gorp is proud to announce the very successful completion of the master thesis project of Sven Bastianen.  Sven has worked closely with SAP NL and for the final presentation the large number of attendees confirmed that he tackled a very relevant problem.

MTP Defense Sven Bastianen (web)
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IS-HEART session by Stan Lamers

The 2nd IS-HEART session of Feb. 2015 will be scheduled in week 4 instead of week 3.

Title: Physician Order Alert Assessment Support using Data Mining Techniques.

Where: K16
When: 27/02/2015, 12:30-13:30
Also see the online agenda item.

Everybody Welome!

Abstract: During the last four decades there has been a major increase in the number of automatic reporting systems for adverse drug events (ADEs)in the healthcare setting. Computerized prescription alerts can assist in avoiding ADEs but research has indicated that one important example of an ADE is the situation where a medical specialist fails to adequately assess computerized prescription alerts. These computerized prescription alerts can be shown to a physician when for example there is a problem with the dosage of a prescribed medicine or an interaction with other medicines is found. Hospital Pharmacist Drs. P.A.G. De Klaver indicates that Maxima Medical Center’s Pharmacy has to deal with 500-800 prescription alerts on an average day, which is considered to be too high and time consuming. The alert system that is currently in use at the hospital is emphasizing the breadth of coverage instead of clinical relevance or severity of the event, which leads to low clinician acceptance of drug alerts. Many alerts can cause alert fatigue; a state in which the user becomes less responsive to alerts in general.
The aim of this research project is to find data mining techniques to create models that can support processing of prescription alerts at the Maxima Medical Center in Veldhoven. This research will not focus on all ADEs but only on drug-drug interaction effects and their alerts because those alerts are considered to be the most time consuming for pharmacy personnel.

In this presentation, an overview of recent work on improving healthcare alerts systems is given and the overall research proposal is clarified.

Preparations for GameBus are heating up!

While work on the GameBus project will officially start in January 2015, we are already making various preparations.  The most important preparation is the recruiting of two new group members.  One group member has been selected from the User System Interaction pool of PDEng trainees.  This member will focus on the end user experience as well as on the business model aspects of GameBus.  A second PDEng trainee was selected from the Software Technology pool.  This member will focus on the integration of game components on the bus.

Besides PDEng projects, we have defined two master thesis projects on GameBus.  One student will focus on GameBus business model aspects as part of a graduation in Innovation Management.  A second student will focus on GameBus backend aspects as part of a graduation in Business Information Systems.

A GameBus kick-off meeting will be organized as a side activity of the EIT ICT Labs Health and Wellbeing End-of-Year Event 2014.  In this way, we involve also our Italian partners in the preparations such that in January 2015 we can take a flying start!

Stay tuned…

IS-HEART Talk on Lean Management by Pieter Dat

On Friday, September 5th 2014, Pieter Dat will present the results of his second master thesis. Pieter has completed his first master thesis in our TU/e IS group (see previous post). Last month, he has completed his second master on Care Management, at Erasmus University Rotterdam. In his second thesis, Pieter has investigated Lean Management at the Maxima Medisch Centrum.

As usual, the IS-HEART session is organized in Paviljoen K16, from 12:30 to 13:30.

Further information:

Abstract master thesis (EUR): evidence in Lean Management (“Lean capacity planning and accessibility of healthcare services:
Development of a continuous improvement culture or application of instruments and tools”)

Research question and objective:
Lean Management is characterised by a continuous improvement culture within an organisation and has resulted in improvements of business processes in several industries. A differentiation in the theory of Lean Management can be made between an organisational and an operational perspective. Lean Management is increasingly applied in the healthcare domain. In the Máxima Medisch Centrum (MMC, Eindhoven / Veldhoven) employees working at the operational level use instruments and tools to apply Lean Management. The central scientific research question is formulated as: “How can Lean Management tools and instruments contribute to continuous process improvement in the Máxima Medisch Centrum?” This research project aimed at analysing how the use of instruments and tools leads to (the development of) continuous improvement in the organisation.

Research design and research methodologies:
The research consisted of case studies at two outpatient departments in the Máxima Medisch Centrum. Four research methodologies are applied, in a triangular approach: 1) semi-structured questionnaire, 2) data analysis of Key Performance Indicators (KPI’s), 3) document analysis and 4) semi-structured interviews.

Results and conclusion:
The master thesis project lead to insights in the current maturity of the application of Lean Management in the Máxima Medisch Centrum. Recommendations, regarding the applicability and prerequisites, are drawn for further development of a continuous improvement culture in the hospital.

IS-HEART Presentation by Juby Joseph Ninan

Title: Integrating simulation and enactment models: a reality check

See Agenda Item


As organizations grow larger and the complexity of their business processes increases, it becomes important to use information systems that can use software tools to control, coordinate, execute and monitor their processes. There are different vendors that offer such business process management software and services to automate a company’s business processes, enhance their visibility and control, and provide support for continuous improvement. Business process simulation plays an important role for analyzing processes for continuous improvement. Here simulation is used to study the dynamic behavior of processes over time, thereby showing how the performance of processes or resources can be influenced by changes in the system or environment.

Business Process Simulation is usually used to support strategic decision making in companies, where the objective is to move the organization towards achieving its long term goals. Here simulation helps to understand how a particular decision affects long term behavior of the process. However, these kinds of simulation experiments are not useful to support management or operational decision making, where short term behavior of processes is to be analyzed.

For short term simulations, we can use information readily made available from the business process management system itself, without the need for additional modeling. The BPMS will have knowledge of the process structure definition, the current state of the process instances and the history records of the process execution, all of which can be used to run short- term simulation experiments. The process structure definition will contain information about the control flow and the data flow. The current state of process instances can be used to load the initial state of the simulation model, and analyzing history records may give us simulation relevant properties such as arrival rate of instances, execution time of activities, etc.

This thesis is an attempt to explore the current simulation capabilities in the BPM Suite jBPM (whose core is a light weight, extensible workflow engine that allows execution of business processes using the BPMN 2.0 specification) and also investigate whether such short term simulation experiments can be supported by the tool.

Master Thesis Completed: From paper-based care pathway to executable workflow process model

On Tuesday, 3/12/2013, Wesley van Renswouw has defended his master thesis on deriving Workflow Management Support from Care Pathway Protocols.
Supervisors TU/e:

  • Dr. P.M.E. Van Gorp, TU/e, Information Systems
  • Dr. O. Türetken, TU/e, Information Systems

Supervisor Philips Research:

  • Dr. R. Vdovjak

Management Summary

Nowadays there are major issues in the healthcare related to quality, performance and costs. Even in countries where the healthcare is well developed and resourced there is clear evidence that the quality remains a serious concern. Too many errors and incidents happen in the clinical working practices, resulting in unnecessary suffering, use of resources, and even deaths. In the USA at least 210,000 deaths each year are a result of preventable hospital errors. In National Health Service hospitals in the UK this number is estimated on 40,000 deaths a year due to medical errors. On top of that the cost of healthcare is increasing each year. It is clear that something has to change in the way healthcare is currently practising its business.

In the 1980s care pathways were introduced for the first time. A care pathway is a description of a care process from an organization point of view for a specific disease and for a specific group of patients. It is based on evidence and on (clinical) guidelines and it is designed to improve efficiency and patient outcomes. The aim of care pathways is to enhance the quality of care across the continuum by improving risk-adjusted patient outcomes, promoting patient safety, increasing patient satisfaction, and optimizing the use of resources. That this aim is getting achieved is demonstrated by many studies on this subject. Using care pathways can significantly improve the quality of care, shorten the length of stay of a patient, and lower the costs of care.

However the majority of care pathways that are developed and implemented are used manually by filling predefined paper documents. In this day and age where other industries have adopted workflow management systems with e.g. automated tasks, decision support, and compliance checking, the usage of paper-based documents seems obsolete. The few studies that are performed
on workflow applications that integrate the care pathways show promising results. Key performance indicators like quality of care, length of stay of patient, use of resources, and costs of care are improved by these new systems.

As mentioned these systems are still in development and mature systems are not yet widely introduced and adopted in the market. The current mismatch between medical research and research done within the field of Information Systems might be the problem. Where the medical research is aimed primarily at developing the care pathways on a clinical level, the research in the

Information Systems field is mainly focused on specific technical aspects of implementing care pathways into executable workflow applications. The part which describes how text-based care pathways can be modelled into executable workflow process models in a structured way is still missing in current research. Therefore in this thesis a methodology is derived which can be followed to transform paper-based care pathways to executable workflow process models in a structured and reproducible way.

The intention behind this methodology is to increase the usability of and compliance with care pathways in the healthcare field. By using the steps proposed in this methodology it is easier for hospitals and industrial partners to develop workflow process models based on paper-based care pathways. Also the developed process models will have a similar structure which would make the models more understandable in the long run since stakeholders will recognise the structure of the models.

The methodology consists of three phases. In phase one the paper-based care pathway is annotated in order to extract the information that is presented in the paper-based care pathway.

Phase two describes the steps how the annotated paper-based care pathway can be modelled in a conceptual process model in a structured and reproducible way. First the sunny day scenario is modelled in the main process. Next the subprocesses are modelled. It is likely that there are multiple child levels in the process model; therefore it is important to follow the structured approach, given in the methodology, to get a consistent model. Business rules should be added in order to comply with the procedures stated in the care pathway. Next extended BPMN constructs and exception handling patterns can be used to model the variance that can occur in the care pathway.

Finally the third phase provides a step-by-step description on how to perform the transformation from a conceptual process model to an executable workflow process model. Topics that are included in these steps are: the soundness and correctness of the conceptual model, the link between the two modelling languages, adjusting the conceptual model, modelling the required data, flexibility, roles and users, forms, business rules, integration with health information systems, and verification and execution of the process.

In order to give a proof of concept the methodology is used in a case study which uses the paper-based unstable angina care pathway as starting point. This care pathway is distributed by the Chinese Ministry of Health and its use is mandatory for all Chinese hospitals. In this case study first the care pathway is annotated. Next the whole case pathway is modelled to a conceptual model. In the last phase a section of the conceptual model is transformed to an executable workflow model.

An internal evaluation by Philips Research states that the annotation phase is an essential step in the methodology because it helps the modeller to get better acquainted with the care pathway he/she wants to model. The annotation steps provide a deeper understanding of information and the structure of the care pathway. The conceptual model is quite suitable for clinical practice and particularly useful for understanding the care pathway and communicating the necessary details among the relevant stakeholders. However the case study performed on the third phase of the methodology is quite limited; therefore the executability of the workflow process model should be tested more extensively and the outcomes should be communicated with the stakeholders before the real value of this phase can be determined. Also the intended use of the workflow process model needs to be further investigated.

Thesis Text

Available from the TU/e library

Pictures from the Thesis Ceremony

03-Dec-2013 15:02, HUAWEI HUAWEI G700-U10 , 2.4, 3.5mm, 0.02 sec, ISO 91
03-Dec-2013 15:03, HUAWEI HUAWEI G700-U10 , 2.4, 3.5mm, 0.02 sec, ISO 91
03-Dec-2013 16:53, HUAWEI HUAWEI G700-U10 , 2.4, 3.5mm, 0.1 sec, ISO 721
03-Dec-2013 16:53, HUAWEI HUAWEI G700-U10 , 2.4, 3.5mm, 0.1 sec, ISO 721
05-Dec-2013 09:32, HUAWEI HUAWEI G700-U10 , 2.4, 3.5mm, 0.03 sec, ISO 105

Master Thesis Defense by Wesley (J.M.) van Renswouw on Deriving WFM support from Care Pathway Protocols

On Tuesday, 3/12/2013, Wesley van Renswouw will defend his master thesis on deriving Workflow Management Support from Care Pathway Protocols. The thesis is based on an official (governmental) care pathway from China. The thesis project has been conducted in collaboration with Philips Research and leverages industry software such as JBoss DROOLS BRMS (jBPM).

Everybody is cordially invited to attend the open session, which is scheduled from 15:00 to 16:00. Event details: see online calendar item.

We wish Wesley all the best for his presentation and defense!